BIOCERH: BIOLOGIA CELULAR EN ENFERMEDADES RENALES E HIPERTENSION

Fundación Jiménez Díaz. Universidad Autónoma de Madrid
Investigadora Responsable: Marta Ruiz Ortega
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Líneas de investigación. Objetivos

  • Búsqueda de nuevos mediadores en el daño renal y cardiovascular.
  • Implicación de la respuesta inmune Th17 en procesos de fibrosis tisular.
  • Evaluación de la ruta de señalización CCN2/EGFR en fibrosis.
  • Estudio de la activación de programas de desarrollo embrionario en la enfermedad renal crónica: GREMLIN y Notch

 

Componentes

 

  • Marta Ruiz Ortega                        
  • Sandra Rayego Mateos
  • Raul Rodrigues
  • Raquel Rodrigues-Diez
  • Matilde Alique Aguilar
  • Carolina Lavoz Barria
  • Macarena Orejudo
  • Jose Morgado Pascual


Publicaciones más relevantes  2013-2015

  1. The C-terminal module IV of connective tissue growth factor is a novel immune modulator of the Th17 response. Lab Invest. 2013;93(7):812-24. Rodrigues-Díez R, Rodrigues-Díez RR, Rayego-Mateos S, Suarez-Alvarez B, Lavoz C, Stark Aroeira L, Sánchez-López E, Orejudo M, Alique M, Lopez-Larrea C, Ortiz A, Egido J, Ruiz-Ortega M.
  2. Gremlin is a downstream profibrotic mediator of transforming growth factor-beta in cultured renal cells. Nephron Exp Nephrol. 2012;122(1-2):62-74. Rodrigues-Diez R, Lavoz C, Carvajal G, Rayego-Mateos S, Rodrigues Diez RR, Ortiz A, Egido J, Mezzano S, Ruiz-Ortega M.
  3. Connective tissue growth factor is a new ligand of Epidermal growth factor receptor. J Mol Cell Biol. 2013 ;5(5):323-335. Rayego-Mateos S, Rodrigues-Díez R, Morgado-Pascual JL, Rodrigues Díez RR, Mas S, Lavoz C, Alique M, Pato J, Keri G, Ortiz A, Egido J, Ruiz-Ortega M.
  4. TWEAK transactivation of the Epidermal growth factor receptor mediates renal inflammation J Pathol. 2013;231(4):480-94 Rayego-Mateos S, Morgado-Pascual JL, Sanz AB, Ramos AM, Eguchi S, Batlle D, Pato J, Keri G, Egido J, Ortiz A, Ruiz-Ortega M
  5. IL-17A is a novel player in dialysis-induced peritoneal damage. Kidney Int. 2014;86(2):303-15 Rodrigues-Díez R, Aroeira LS, Orejudo M, Bajo MA, Heffernan JJ, Rodrigues-Díez RR, Rayego-Mateos S, Ortiz A, Gonzalez-Mateo G, López-Cabrera M, Selgas R, Egido J, Ruiz-Ortega M.
  6. Integrin-linked kinase plays a key role in the regulation of angiotensin II-induced renal inflammation. Clin Sci (Lond). 2014;127(1):19-31. Alique M, Civantos E, Sanchez-Lopez E, Lavoz C, Rayego-Mateos S, Rodrigues-Díez R, García-Redondo AB, Egido J, Ortiz A, Rodríguez-Puyol D, Rodríguez-Puyol M, Ruiz-Ortega M.
  7. Angiotensin II, via angiotensin receptor type 1/nuclear factor-κB activation, causes a synergistic effect on interleukin-1-β-induced inflammatory responses in cultured mesangial cells. J Renin Angiotensin Aldosterone Syst. 2014 Oct 29 Alique M, Sánchez-López E, Rayego-Mateos S, Egido J, Ortiz A, Ruiz-Ortega M.
  8. The C-Terminal Module IV of Connective Tissue Growth Factor, Through EGFR/Nox1 Signaling, Activates the NF-κB Pathway and Proinflammatory Factors in Vascular Smooth Muscle Cells. Antioxid Redox Signal. 2015;22(1):29-47. Rodrigues-Diez RR, Garcia-Redondo AB, Orejudo M, Rodrigues-Diez R, Briones AM, Bosch-Panadero E, Kery G, Pato J, Ortiz A, Salaices M, Egido J, Ruiz-Ortega M
  9. Gremlin activates the Smad pathway linked to epithelial mesenchymal transdifferentiation in cultured tubular epithelial cells. Biomed Res Int. 2014;2014:802841. Rodrigues-Diez R, Rodrigues-Diez RR, Lavoz C, Carvajal G, Droguett A, Garcia-Redondo AB, Rodriguez I, Ortiz A, Egido J, Mezzano S, Ruiz-Ortega M.
  10. TGF-β Blockade Increases Renal Inflammation Caused by the C-Terminal Module of the CCN2. Rodrigues-Díez R, Rayego-Mateos S, Orejudo M, Aroeira LS, Selgas R, Ortiz A, Egido J, Ruiz-Ortega M. Mediators Inflamm. 2015;2015:506041
  11. Paricalcitol Inhibits Aldosterone-Induced Proinflammatory Factors by Modulating Epidermal Growth Factor Receptor Pathway in Cultured Tubular Epithelial Cells. Biomed Res Int. 2015;2015:783538. Morgado-Pascual JL, Rayego-Mateos S, Valdivielso JM, Ortiz A, Egido J, Ruiz-Ortega
  12. Gremlin regulates renal inflammation via the vascular endothelial growth factor receptor 2 pathway. J Pathol. 2015;236(4):407-20. Lavoz C, Alique M, Rodrigues-Diez R, Pato J, Keri G, Mezzano S, Egido J, Ruiz-Ortega M.

 

Publicaciones más relevantes 2010-2012

  1. Berzal S, Alique M, Ruiz-Ortega M, Egido J, Ortiz A, Ramos AM. GSK3, Snail and adhesion molecule regulation by Cyclosporine A in renal tubular cells. Toxicol Sci. 2012
  2. Izquierdo MC, Sanz AB, Mezzano S, Blanco J, Carrasco S, Sanchez-Niño MD, Benito-Martín A, Ruiz-Ortega M, Egido J, Ortiz A. TWEAK (tumor necrosis factor-like weak inducer of apoptosis) activates CXCL16 expression during renal tubulointerstitial inflammation. Kidney Int. 2012
  3. Tavira B, Coto E, Torres A, Díaz-Corte C, Díaz-Molina B, Ortega F, Arias M, Díaz JM, Selgas R, López-Larrea C, Ruiz-Ortega M, Ortiz A, González E, Campistol JM, Alvarez V; Pharmacogenetics of tacrolimus REDINREN study group. Association between a common KCNJ11 polymorphism (rs5219) and new-onset posttransplant diabetes in patients treated with Tacrolimus. Mol Genet Metab. 2012
  4. Sanchez-Niño MD, Sanz AB, Sanchez-Lopez E, Ruiz-Ortega M, Benito-Martin A, Saleem MA, Mathieson PW, Mezzano S, Egido J, Ortiz A. HSP27/HSPB1 as an adaptive podocyte antiapoptotic protein activated by high glucose and angiotensin II. Lab Invest. 2012;92(1):32-45.
  5. Moreno JA, Izquierdo MC, Sanchez-Niño MD, Suárez-Alvarez B, Lopez-Larrea C, Jakubowski A, Blanco J, Ramirez R, Selgas R, Ruiz-Ortega M, Egido J, Ortiz A,Sanz AB. The inflammatory cytokines TWEAK and TNFα reduce renal klotho expression through NFκB. J Am Soc Nephrol. 2011; 22(7):1315-25.
  6. Rodrigues Díez R, Rodrigues-Díez R, Lavoz C, Rayego-Mateos S, Civantos E, Rodríguez-Vita J, Mezzano S, Ortiz A, Egido J, Ruiz-Ortega M. Statins inhibit angiotensin II/Smad pathway and related vascular fibrosis, by a TGF-β-independent process. PLoS One. 2010;5(11):e14145.
  7. Palacín M, Alvarez V, Martín M, Díaz M, Corao AI, Alonso B, Díaz-Molina B, Lozano I, Avanzas P, Morís C, Reguero JR, Rodríguez I, López-Larrea C, Cannata-Andía J, Batalla A, Ruiz-Ortega M, Martínez-Camblor P, Coto E. Mitochondrial DNA and TFAM gene variation in early-onset myocardial infarction: evidence for an association to haplogroup H. Mitochondrion. 2011, 11(1):176-81.
  8. Sanchez-Niño MD, Sanz AB, Carrasco S, Saleem MA, Mathieson PW, Valdivielso JM, Ruiz-Ortega M, Egido J, Ortiz A. Globotriaosylsphingosine actions on human glomerular podocytes: implications for Fabry nephropathy. Nephrol Dial Transplant. 2011; 26(6):1797-802.
  9. Gonçalves S, Fernandez-Sanchez R, Sanchez-Niño MD, Tejedor A, Neria F, Egido J, Ruiz-Ortega M, Ortiz A. Tyrphostins as potential therapeutic agents for acute  kidney injury. Curr Med Chem. 2010;17(10):974-86.
  10. Ardura JA, Rayego-Mateos S, Rámila D, Ruiz-Ortega M, Esbrit P. Parathyroid hormone-related protein promotes epithelial-mesenchymal transition. J Am Soc Nephrol. 2010;21(2):237-48.