FIBROCOR: REGULACION MOLECULAR DEL DESARROLLO DEL CORAZON Y DE LAS ENFERMEDADES CARDIACAS

Fundación  Centro Nacional de Investigaciones Cardiovasculares.
Investigadores  responsables: Enrique Lara-Pezzi y Nadia Mercader Huber

Lineas de investigación

Componentes

  • Marina Peralta  López
  • Juan Manuel  Gonzalez Rosa
  • Jesús M. Gómez Salinero
  • Laura Padrón Preveraud
  • Enrique Alfonso Lara Pezzi
  • Nadia Mercader Huber
  • Inés Joao Dos Santos Marques

Publicaciones más relevantes 2013-2015

  1. Guidelines for Transaltional Research in Heart Failure Lara-Pezzi E, Menasché P, Trouvin JH, Badimón L, Ioannidis JP, Wu JC, Hill JA, Koch WJ, De Felice AF, de Waele P, Steenwinckel V, Hajjar RJ J Cardiovasc Transl Res (2015) 8:3-22.
  2. Induction of the calcineurin variant CnAbeta1 after myocardial infarction reduces post-infarction ventricular remodelling by promoting infarct vascularization. Lopez-Olaneta MM, Villalba M, Gomez-Salinero JM, Jimenez-Borreguero LJ, Breckenridge R, Ortiz-Sanchez P, Garcia-Pavia P, Ibanez B, Lara-Pezzi E.Cardiovasc Res (2014) 102:396-406
  3. FineSplice, enhanced splice junction detection and quantification: a novel pipeline based on the assessment of diverse RNA-Seq alignment solutions. Gatto A, Torroja-Fungairiño C, Mazzarotto F, Cook SA, Barton PJ, Sánchez-Cabo F, Lara-Pezzi E. . Nucleic Acids Res (2014) 42:e71.
  4. The Alternative Heart: Impact of Alternative Splicing in Heart Disease. Lara-Pezzi E, Gómez-Salinero J, Gatto A, García-Pavía P. J Cardiovasc Transl Res (2013) 6:945-55.
  5. Telomerase is Essential for Zebrafish Heart Regeneration. Bednarek D, González-Rosa JM, Guzmán-Martínez G, Gutiérrez-Gutiérrez Ó, Aguado T, Sánchez-Ferrer C, Marques IJ, Galardi-Castilla M, de Diego I, Gómez MJ, Cortés A, Zapata A, Jiménez-Borreguero LJ, Mercader N, Flores I Cell Rep. 2015;12(10):1691-703.
  6. Use of echocardiography  reveals reestablishment of ventricular pumping efficency and partial ventricular  wall motion recovery upon ventricular  cryoinjury in the zebrafish González-Rosa JM, Guzmán-Martínez G, Marques IJ, Sánchez-Iranzo H, Jiménez-Borreguero LJ, Mercader N PLoS One. 2014; 9(12):e115604.
  7. Transcriptional response to cardiac injury in the zebrafish: systematic identification of genes with highly concordant activity across in vivo models Rodius S, Nazarov PV, Nepomuceno-Chamorro IA, Jeanty C, González-Rosa JM, Ibberson M, da Costa RM, Xenarios I, Mercader N, Azuaje F BMC Genomics. 2014: 852. 
  8. The Epicardium in the Embryonic and Adult Zebrafish. Peralta M, González-Rosa JM, Marques IJ, Mercader N. J Dev Biol. 2014; 2(2):101-116.
  9. Binary recombinase systems for high-resolution conditional mutagenesis Hermann M, Stillhard P, Wildner H, Seruggia D, Kapp V, Sánchez-Iranzo H,Mercader N, Montoliu L, Zeilhofer HU, Pelczar P. Nucleic Acids Res. 2014 42(6):3894-907.
  10. Heartbeat-driven pericardiac fluid forces contribute to epicardium morphogenesis. Peralta M, Steed E, Harlepp S, González-Rosa JM, Monduc F, Ariza-Cosano A,
    Cortés A, Rayón T, Gómez-Skarmeta JL, Zapata A, Vermot J, Mercader N. Curr Biol. 2013; 23(18):1726-35.

.Publicaciones más relevantes 2010-2012

  1. Epithelial- and Endothelial- to Mesenchymal Transition: from Cardiovascular Development to Disease. Kovacic JC, Mercader N, Torres M, Boehm M, Fuster V. Circulation 2012
  2. Cryoinjury as a myocardial infarction model for the study of cardiac regeneration in the zebrafish. González-Rosa and Mercader, N. Nature protocols (en prensa)
  3. The Osr1 and Osr2 genes act in the pronephric anlage downstream of retinoic acid signaling and upstream of Wnt2b to maintain pectoral fin development. Neto A, Mercader N, Gómez-Skarmeta JL. Development. 2012; 139(2):301-11
  4. Extensive scar formation and regression during heart regeneration after cryoinjury in zebrafish.González-Rosa JM, Martín V, Peralta M, Torres M, Mercader N. Development. 2011; 138(9):1663-74.
  5. Lineage tracing of epicardial cells during development and regeneration.González-Rosa JM, Padrón-Barthe L, Torres M, Mercader N. Rev Esp Cardiol. 2010 . 63 Suppl 2:36-48.
  6. Calcineurin splicing variant calcineurin Aβ1 improves cardiac function after myocardial infarction without inducing hypertrophy. Felkin LE, Narita T, Germack R, Shintani Y, Takahashi K, Sarathchandra P, López-Olañeta MM, Gómez-Salinero JM, Suzuki K, Barton PJ, Rosenthal N, Lara-Pezzi E. Circulation. 2011;123(24):2838-47.
  7. Reverse remodelling and recovery from heart failure are associated with complex patterns of gene expression. Felkin LE, Lara-Pezzi E, Hall JL, Birks EJ, Barton PJ. J Cardiovasc Transl Res. 2011 Jun;4(3):321-31.
  8. Cardiac myocyte-specific ablation of follistatin-like 3 attenuates stress-induced myocardial hypertrophy. Shimano M, Ouchi N, Nakamura K, Oshima Y, Higuchi A, Pimentel DR, Panse KD, Lara-Pezzi E, Lee SJ, Sam F, Walsh K. J Biol Chem. 2011; 286(11):9840-8.
  9. Revealing new mouse epicardial cell markers through transcriptomics. Bochmann L, Sarathchandra P, Mori F, Lara-Pezzi E, Lazzaro D, Rosenthal N. PLoS One. 2010 ;5(6):e11429.