FIBROREN: GRUPO DE FISIOPATOLOGÍA RENAL Y VASCULAR

Universidad de Álcala, Unidad de Investigación. Hospital Príncipe de Asturias
Investigador Principal: Diego Rodríguez Puyol
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Líneas de investigación. Objetivos

  • Este grupo trabaja de forma coordinada con la Fundación de investigación del Hospital Príncipe de Asturias desde la creación de ésta última en 2004.
  • Objetivo principal: Estudio del efecto de la matriz extracelular sobre la modulación fenotípica de las células vasculares y renales, y su influencia en la generación de los procesos de fibrosis en el envejecimiento y en la función vascular.

Componentes

  • José Luís Cano
  • Maria Piedad Ruiz Torres
  • Nuria Troyano
  • Gemma  Olmos Centenera
  • Laura Calleros
  • M. Alicia Cortés
  • M. Luisa Diez Marques
  • Sergio  De Frutos
  • Manuel  Rodríguez Puyol
  • Maria Del Nogal Avila
  • Diego Rodríguez Puyol
  • Paloma Martin Sánchez

Publicaciones más relevantes 2013-2015

  1. Glucose Oxidase Induces Cellular Senescence in Immortal Renal Cells through ILK by Downregulating Klotho Gene ExpressionTroyano-Suárez N, Del Nogal-Avila M, Mora I, Sosa P, López-Ongil S, Rodriguez-Puyol D, Olmos G, Ruíz-Torres MP.Oxid Med Cell Longev. 2015; 2015:416738.
  2. Improvement of mineral and bone metabolism markers is associated with better survival in haemodialysis patients: the COSMOS study. Fernández-Martín JL, Martínez-Camblor P, Dionisi MP, Floege J, Ketteler M, London G, Locatelli F, Gorriz JL, Rutkowski B, Ferreira A, Bos WJ, Covic A, Rodríguez-García M, Sánchez JE, Rodríguez-Puyol D, Cannata-Andia JB; COSMOS group.  Nephrol Dial Transplant. 2015 Sep;30(9):1542-51.
  3. Renal integrin-linked kinase depletion induces kidney cGMP axis upregulation: Consequences on basal and acutely damaged renal function Cano-Peñalver JL, Griera M, García-Jerez A, Hatem-Vaquero M, Ruiz-Torres MP, Rodríguez-Puyol D, De Frutos S, Rodríguez-Puyol M. Mol Med. 2015 Oct 10
  4. Hyperphosphatemia induces cellular senescence in human aorta smooth muscle cells through integrin linked kinase (ILK) up-regulation. Troyano N, Nogal MD, Mora I, Diaz-Naves M, Lopez-Carrillo N, Sosa P, Rodriguez-Puyol D, Olmos G, Ruiz-Torres MP.  Mech Ageing Dev. 2015 Oct 20;152:43-55.
  5. MicroRNAs 29b, 133b, and 211 Regulate Vascular Smooth Muscle Calcification Mediated by High Phosphorus. Panizo S, Naves-Díaz M, Carrillo-López N, Martínez-Arias L, Fernández-Martín JL, Ruiz-Torres MP, Cannata-Andía JB, Rodríguez I.  J Am Soc Nephrol. 2015 Jul 17. pii: ASN.2014050520.
  6. Hyperosmolarity induced by high glucose promotes senescence in human glomerular mesangial cells del Nogal M, Troyano N, Calleros L, Griera M, Rodriguez-Puyol M, Rodriguez-Puyol D, Ruiz-Torres MP. . Int J Biochem Cell Biol. 2014; 54:98-110.
  7. Ilk conditional deletion in adult animals increases cyclic GMP-dependent vasorelaxation Serrano I, De Frutos S, Griera M, Medrano D, Rodríguez-Puyol M, Dedhar S, Ruiz-Torres MP, Rodríguez-Puyol D.. Cardiovasc Res. 2013; 99(3):535-44.
  8. Amadori products promote cellular senescence activating insulin-like growth factor-1 receptor and down-regulating the antioxidant enzyme catalase Del Nogal-Ávila M, Troyano-Suárez N, Román-García P, Cannata-Andía JB, Rodriguez-Puyol M, Rodriguez-Puyol D, Kuro-O M, Ruiz-Torres MP.  Int J Biochem Cell Biol. 2013; 45(7):1255-64.
  9. Relevant role of PKG in the progression of fibrosis induced by TNF-like weak inducer of apoptosis Martín P, Mora I, Cortes MA, Calleros L, García-Jerez A, Ortiz A, Rodríguez-Puyol M, Rodríguez-Puyol D, Olmos G. Am J Physiol Renal Physiol. 2014; 307(1):F75-85.
  10. Integrin-linked kinase plays a key role in the regulation of angiotensin II-induced renal inflammation. Alique M, Civantos E, Sanchez-Lopez E, Lavoz C, Rayego-Mateos S, Rodrigues-Díez R, García-Redondo AB, Egido J, Ortiz A, Rodríguez-Puyol D, Rodríguez-Puyol M, Ruiz-Ortega M. Clin Sci (Lond). 2014;127(1):19-31

Publicaciones más relevantes 2010-2012

  1. González-Ramos M, Mora I, de Frutos S, Garesse R, Rodríguez-Puyol M, Olmos G, Rodríguez-Puyol D. Intracellular redox equilibrium is essential for the constitutive expression of AP-1 dependent genes in resting cells: Studies on TGF-β1 regulation. Int J Biochem Cell Biol. 2012;44(6):963-71.
  2. García G, Serrano I, Sánchez-Alonso P, Rodríguez-Puyol M, Alajarín R, Griera M, Vaquero JJ, Rodríguez-Puyol D, Alvarez-Builla J, Díez-Marqués ML. New losartan-hydrocaffeic acid hybrids as antihypertensive-antioxidant dual drugs: Ester, amide and amine linkers. Eur J Med Chem. 2012;50:90-101.
  3. Calleros L, Cortés MA, Luengo A, Mora I, Guijarro B, Martín P, Ortiz-Arduán A, Selgas R, Rodríguez-Puyol D, Rodríguez-Puyol M. Start-up of a clinical simple processing, storage and management platform: organisation and development of the REDinREN Biobank. Nefrologia. 2012;32(1):28-34.
  4. Raoch V, Rodríguez-Pascual F, López-Martínez V, Medrano-Andrés D, Rodríguez-Puyol M, Lamas S, Rodríguez-Puyol D, López-Ongil S. Nitric oxide decreases the expression of endothelin-converting enzyme-1 through mRNA destabilization. Arterioscler Thromb Vasc Biol. 2011; 31(11):2577-85.
  5. Alique M, Calleros L, Luengo A, Griera M, Iñiguez MÁ, Punzón C, Fresno M,Rodríguez-Puyol M, Rodríguez-Puyol D. Changes in extracellular matrix composition regulate cyclooxygenase-2 expression in human mesangial cells. Am J Physiol Cell  Physiol. 2011; 300(4):C907-18.
  6. Grande MT, Fuentes-Calvo I, Arévalo M, Heredia F, Santos E, Martínez-Salgado C, Rodríguez-Puyol D, Nieto MA, López-Novoa JM. Deletion of H-Ras decreases renal fibrosis and myofibroblast activation following ureteral obstruction in mice.Kidney Int. 2010;77(6):509-18.
  7. Chamorro-Jorganes A, Grande MT, Herranz B, Jerkic M, Griera M, Gonzalez-Nuñez M, Santos E, Rodriguez-Puyol D, Lopez-Novoa JM, Rodriguez-Puyol M. Targeted genomic disruption of h-ras induces hypotension through a NO-cGMP-PKGpathway-dependent mechanism. Hypertension. 2010 Sep;56(3):484-9.
  8. Chamorro-Jorganes A, Calleros L, Griera M, Saura M, Luengo A, Rodriguez-Puyol D, Rodriguez-Puyol M. Fibronectin upregulates cGMP-dependent protein kinase type Iβ through C/EBP transcription factor activation in contractile cells. Am J Physiol Cell Physiol. 2011; 300(3):C683-91.
  9. Martín-Garrido A, González-Ramos M, Griera M, Guijarro B, Cannata-Andia J, Rodriguez-Puyol D, Rodriguez-Puyol M, Saura M. H2O2 regulation of vascular function through sGC mRNA stabilization by HuR. Arterioscler Thromb Vasc Biol. 2011;31(3):567-73.